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By reporting side effects you can help provide more information on the safety of this medicine.
Venlafaxine oral tablet is used to treat depression immediate-release tablet and extended-release tablet.
Important warnings.
Do not use Effexor XR for a condition for which it was not prescribed.
No accumulation of venlafaxine has been observed during chronic administration in healthy subjects.
Your healthcare provider or pharmacist can tell you if it is safe to take Effexor XR with your other medicines.
A statistically significant greater risk for attempted suicide remained after adjustment, but the authors concluded that it could be due to residual confounding.
Effexor XR Images.
When taken during pregnancy, similar drugs SSRIs may increase the risk of a serious condition in babies, called persistent pulmonary hypertension of the new born PPHN , making the baby breathe faster and appear bluish.
Venlafaxine tablets and capsules can be either immediate release or extended release.
Consult a Certified Poison Control Center for up-to-date guidance and advice or www.
It is unknown whether the suicidality risk extends to longer term use, i.
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Steady-state concentrations of venlafaxine and ODV in plasma are attained within 3 days of oral multiple-dose therapy.
Signs and symptoms of hyponatremia include headache, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which may lead to falls.
Skip the missed dose if it is almost time for your next scheduled dose.
Sexual side effects usually pass after the first couple of weeks.
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Here are 8 photographs of what feelings of turmoil may look like.
Patients receiving continued Effexor treatment experienced statistically significantly lower relapse rates over the subsequent 52 weeks compared with those receiving placebo study 5.
Approval History FDA approved
At the same time, fluoxetine Prozac halved the suicide risk.
Epidemiological studies have shown that venlafaxine-treated patients have a higher preexisting burden of suicide risk factors than SSRI-treated patients.
If you have hyperthyroidism and take venlafaxine, your heart rate may increase to a dangerous level.
Canadian Journal of Psychiatry.
Here are six habits that secretly take over how we interact with….
Effexor side effects in more detail.
Venlafaxine will not affect contraception including the combined pill or emergency contraception.
Cardiovascular system — QT prolongation, ventricular fibrillation, ventricular tachycardia including torsade de pointes , takotsubo cardiomyopathy.
See also: Effexor drug interactions in more detail.
Do not stop venlafaxine without talking to your doctor.
It can be potentially dangerous to take venlafaxine with: stimulants like MDMA ecstasy or cocaine hallucinogens like LSD novel psychoactive substances which used to be known as legal highs like mephedrone.
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It may take several weeks before your symptoms improve.
It comes as tablets and capsules which are available only on prescription.
If you provide a urine sample for drug screening, tell the laboratory staff that you are taking this medicine.
It should not be used in conjunction with a monoamine oxidase inhibitor MAOI , as it can cause potentially fatal serotonin syndrome.
If the decision has been made to discontinue treatment, medication should be tapered, as rapidly as is feasible, but with recognition that abrupt discontinuation can be associated with certain symptoms [see Warnings and Precautions 5.
Some people feel worse during the first few weeks of treatment before they begin to feel better.
You must tell your doctor if you are taking medicines that can affect your heart rhythm.
You can take supplements to increase your serotonin levels.
You are especially at risk if you take venlafaxine doses greater than mg per day.
Adjunctive therapies Atypical antipsychotics aripiprazole , brexpiprazole , lurasidone , olanzapine , quetiapine , risperidone Buspirone Lithium lithium carbonate , lithium citrate Thyroid hormones triiodothyronine T 3 , levothyroxine T 4.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Figure 2: Effect of venlafaxine on the pharmacokinetics interacting drugs and their active metabolites.
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Venlafaxine may be used as part of a combination therapy.
My 6 Hidden Struggles of Depression.
The structural formula is shown as follows:.
If this happens, your doctor may have you start taking venlafaxine again and decrease your dosage slowly.
Immediate release tablets release the venlafaxine into your system as soon as you swallow them.
Effexor XR was associated with mean final on-therapy increases in fasting serum triglycerides compared with placebo in premarketing clinical studies of SAD and PD up to 12 weeks pooled data and 6 months duration Table
Ask your doctor before making any changes in how or when you take your medications.
Venlafaxine and ODV exhibited linear kinetics over the dose range of 75 to mg per day.
Seizures have occurred with venlafaxine therapy.
Plasma levels of the O-desmethyl metabolite ODV were lower in rats than in patients receiving the maximum recommended dose.
Remember to take the packet with you, even if it is empty.
In controlled trials, there were dose-related increases in systolic and diastolic blood pressure, as well as cases of sustained hypertension [see Adverse Reactions 6.
The average change in body weight and incidence of weight loss percentage of patients who lost 3.
Do not stop Effexor XR without first talking to your healthcare provider.
The use of MAOIs intended to treat psychiatric disorders concomitantly with Effexor XR or within 7 days of discontinuing treatment with Effexor XR is contraindicated because of an increased risk of serotonin syndrome.
Product Characteristics.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use venlafaxine only for the indication prescribed.
Your doctor will write the number of refills authorized on your prescription.
Common side effects include loss of appetite, constipation, dry mouth , dizziness, sweating, and sexual problems.
False positive test results may be expected for several days following discontinuation of venlafaxine therapy.
If any of the following happen, do not take more Venlafaxine.
Two 6-month studies, one evaluating Effexor XR doses of
Urogenital system — Urinary retention, urination impaired, urinary incontinence, urinary frequency increased, menstrual disorders associated with increased bleeding or increased irregular bleeding e.
My 6 Hidden Struggles of Depression When depression strikes, it can affect our mood and habits more than we realize.
Depression can make you less motivated to do things.
Ask your pharmacist to recommend a painkiller.
Discontinuation effects have been reported in patients receiving venlafaxine [see Dosage and Administration 2.
A class of drugs is a group of medications that work in a similar way.
Treatment with Effexor XR and any concomitant serotonergic agents should be discontinued immediately if the above events occur, and supportive symptomatic treatment should be initiated.
Venlafaxine oral tablet can interact with other medications, vitamins, or herbs you may be taking.
In reproductive developmental studies in rats and rabbits with O-desmethylvenlafaxine ODV , the major human metabolite of venlafaxine, evidence of teratogenicity was not observed at exposure margins of 13 in rats and 0.
For people with increased eye pressure glaucoma : Venlafaxine can widen your pupils and block the flow of fluid in your eye.
Ask your pharmacist how to throw away medicines you no longer use.
Drug Class.
Do not drink too much alcohol.
Taking venlafaxine with certain medications raises your risk of side effects.
Talk to your doctor about breastfeeding your child.
Among the other reported symptoms were paresthesia of all four limbs, moderate dizziness, nausea, numb hands and feet, and hot-cold spells 5 days after the overdose.
The pharmacokinetics of venlafaxine and ODV are not substantially altered in the elderly [see Clinical Pharmacology
Urgent advice: Call your doctor straight away if:.
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For a full list see the leaflet inside your medicines packet.
If concomitant use of Effexor XR with other serotonergic drugs e.
How to tell if the drug is working: The symptoms of your depression or anxiety should be less severe or happen less often.
Related: Autism Autism Spectrum Disorder.
Sigma receptor modulators.
This is because the amount of these drugs in your body may be decreased.
Patients should be monitored for these symptoms when discontinuing treatment with Effexor XR.
Venlafaxine is used to treat major depressive disorder , anxiety and panic disorder.
Venlafaxine is an antidepressant that belongs to a group of medicines called serotonin and norepinephrine reuptake inhibitors SNRIs.
Advise patients that elevations in total cholesterol, LDL and triglycerides may occur and that measurement of serum lipids may be considered [see Warnings and Precautions 6.
What to do if you miss a dose: Take your dose as soon as you remember.
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Based on the mechanism of action of Effexor XR and the potential for serotonin syndrome, caution is advised when Effexor XR is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, SSRIs, other SNRIs, linezolid an antibiotic which is a reversible non-selective MAOI , lithium, tramadol, or St.
It is not common, but some people less than 1 in may have serious side effects when taking venlafaxine.
Driving and using machines Do not drive or use any tools or machines until you know how this medicine affects you.
Tell your doctor right away if you become pregnant while taking this medicine.
Expert Review of Neurotherapeutics.
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Effexor XR is an extended-release capsule for once-a-day oral administration that contains venlafaxine hydrochloride, a serotonin and norepinephrine reuptake inhibitor SNRI.
Effexor XR can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly.
Venlafaxine oral tablet comes in immediate-release and extended-release forms.
Alpha-1 blockers e.
Your doctor will probably recommend reducing your dose gradually over several weeks - or longer, if you have been taking venlafaxine for a long time.
Effexor XR, like many antidepressants, should be used cautiously in patients with a history of seizures and should be discontinued in any patient who develops seizures.
Prescribers or other healthcare professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Effexor XR and should counsel them in its appropriate use.
Digestive system — Gastrointestinal hemorrhage [see Warnings and Precautions 5.
However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional.
Other brands: Effexor , Effexor XR.
Seizures are managed with benzodiazepines or other anticonvulsants.
If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital straight away.
These medicines are thought to work by increasing the levels of mood-enhancing chemicals called serotonin and noradrenaline in the brain.
Efficacy was established in three short-term 4, 8, and 12 weeks and two long-term, maintenance trials.
Never try to catch up by taking two doses at once.
The usual recommended starting dose is 75mg per day.
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Therefore, the dosage of your diabetes medicines may need to be adjusted.
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The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
There were differences in absolute risk of suicidality across the different indications, with the highest incidence in MDD.
However, if it is time for your next dose, skip the missed dose and take only a single dose as usual.
The originating document has been archived.
In patients of all ages who are started on antidepressant therapy monitor closely for clinical worsening and emergence of suicidal thoughts and behaviors.
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This may increase the risk of tooth decay dental caries.
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Families and caregivers of patients being treated with antidepressants for MDD or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of agitation, irritability, unusual changes in behavior, and the other symptoms described above, as well as the emergence of suicidality, and to report such symptoms immediately to healthcare providers.
Drug Saf.
Children and adolescents Venlafaxine should normally not be used for children and adolescents under 18 years.
For people with kidney disease: If you have kidney disease or a history of kidney disease, you may not be able to clear this drug from your body well.
Effexor XR should be administered in a single dose with food, either in the morning or in the evening at approximately the same time each day [see Clinical Pharmacology
No dose adjustment is recommended for the elderly on the basis of age alone, although other clinical circumstances, some of which may be more common in the elderly, such as renal or hepatic impairment, may warrant a dose reduction [see Dosage and Administration 2.
For seniors: The kidneys of older adults may not work as well as they used to.
In a longer term study study 3 , adult outpatients meeting DSM-IV criteria for PD who had responded during a week open phase with Effexor XR 75 to mg per day were randomly assigned to continue the same Effexor XR dose 75, , or mg or switch to placebo for observation for relapse under double-blind conditions.
Side effects such as feeling sick, headaches, sweating, and dry mouth are common.
There is a risk of an effect on the baby.
Some medicines can interact with venlafaxine and cause a serious condition called serotonin syndrome.
Atypical antipsychotics aripiprazole , brexpiprazole , lurasidone , olanzapine , quetiapine , risperidone Buspirone Lithium lithium carbonate , lithium citrate Thyroid hormones triiodothyronine T 3 , levothyroxine T 4.
Effexor XR should also not be started in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue.
Talk to your healthcare provider if you do not think that your condition is getting better with Effexor XR treatment.
Case reports and epidemiological studies case-control and cohort design have demonstrated an association between use of drugs that interfere with serotonin reuptake and the occurrence of gastrointestinal bleeding.
After you start treatment, you may feel worse before you feel better.
The efficacy of Effexor XR as a treatment for Generalized Anxiety Disorder GAD was established in two 8-week, placebo-controlled, fixed-dose studies 75 to mg per day , one 6-month, placebo-controlled, flexible-dose study 75 to mg per day , and one 6-month, placebo-controlled, fixed-dose study
In moderately depressed outpatients, the initial dose of venlafaxine was 75 mg per day.
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In another study, the data on more than , cases were obtained from the UK general practice research database.
For more information about Effexor XR call or go to www.
Tumors were not increased by venlafaxine treatment in mice or rats.
In rare cases, drug-induced akathisia can occur after use in some people.
Across all clinical studies with Effexor, 1.
Effexor XR is also used to treat:.
Such complications can arise immediately upon delivery.
The neurotransmitters affected are serotonin and norepinephrine.
Not all pack sizes may be marketed.
Increases Compared to Placebo.
Pharmacologic activity at these receptors is hypothesized to be associated with the various anticholinergic, sedative, and cardiovascular effects seen with other psychotropic drugs.
Healthcare professionals are advised to prescribe Effexor and Effexor XR in the smallest quantity of capsules consistent with good patient management to reduce the risk of overdose.
Venlafaxine is not recommended in patients hypersensitive to it, nor should it be taken by anyone who is allergic to the inactive ingredients, which include gelatin , cellulose , ethylcellulose, iron oxide , titanium dioxide and hypromellose.
Take the venlafaxine packet, or the leaflet inside it, plus any remaining medicine with you.
Sustained blood pressure elevation can lead to adverse outcomes.
It is also sometimes used to treat anxiety and panic attacks.
Venlafaxine is one of a group of antidepressants called serotonin and noradrenaline reuptake inhibitors, or SNRIs.
For people with a history of seizures: Venlafaxine raises your risk of seizures.
In the clinical studies establishing efficacy, upward titration was permitted at intervals of 2 weeks or more.
Coadministration of Effexor XR and weight loss agents is not recommended.
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Venlafaxine extended release is chemically the same as normal venlafaxine.
This can lead to death.
You can report any suspected side effect to the UK safety scheme.
Control pre-existing hypertension before initiating treatment with Effexor XR.
Venlafaxine side effects in more detail.
Availability Prescription only.
Archived PDF from the original on 16 March
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Patients should be made aware of the potential risk of serotonin syndrome.
Venlafaxine indirectly affects opioid receptors as well as the alpha2-adrenergic receptor, and was shown to increase pain threshold in mice.
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People with a history of increased eye pressure or glaucoma should have their eye pressure checked regularly while taking venlafaxine.
See also: Effexor side effects in more detail.
Venlafaxine has not been properly tested with recreational drugs.
A study conducted in Finland followed more than 15, patients for 3.
Advise patients that they should have regular monitoring of blood pressure when taking Effexor XR [see Warnings and Precautions 5.
Breastfeeding will also benefit both you and your baby.
This is to help prevent any extra side effects you might get as a reaction to coming off the medicine.
Tell your healthcare provider about all the medicines that you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

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Venlafaxine must be discontinued if significant hypertension persists.
These are not all the side effects of venlafaxine.
Effexor XR treatment for up to 12 weeks in premarketing placebo-controlled panic disorder trials was associated with mean final on-therapy increases in serum cholesterol concentration of approximately 5.
You should always consult your doctor or other healthcare professional before taking any medication.
Archived from the original on 17 September
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physically , more depressed, or have thoughts about suicide or hurting yourself.
This increase was duration dependent over the study period and tended to be greater with higher doses.
Most doctors recommend that you take antidepressants for 6 months to 1 year after you no longer feel depressed.
An interaction is when a substance changes the way a drug works.
Expert Opinion on Pharmacotherapy.
How long will I take it for?
This includes prescription and over-the-counter medicines, vitamins, and herbal products.
This can cause your body to process drugs more slowly.
Therapeutic Advances in Psychopharmacology.
You may need to take venlafaxine during pregnancy if you need it to remain well.
What happens when you leave depression untreated?
Stopping before that time can make depression come back.
Page last reviewed: 11 December Next review due: 11 December
Venlafaxine can pass into breast milk and may harm a nursing baby.
Important Do not stop taking venlafaxine suddenly, or without talking to your doctor first.
Cases of elevated blood pressure requiring immediate treatment have been reported with Effexor XR.
Venlafaxine passes into breast milk in small amounts.
Antidepressants N06A.
If you experience any of these or other symptoms that are troublesome, ask your doctor for further advice.
Anyone considering the use of Effexor XR in a child or adolescent must balance the potential risks with the clinical need [see Boxed Warning , Warnings and Precautions 5.
It may harm them.
Archives of General Psychiatry.
Side effects, however, are reported to be more severe in CYP2D6 poor metabolisers.
In the six-month, open-label MDD study, children and adolescents had height increases that were less than expected, based on data from age- and sex-matched peers.
The number of patients receiving multiple doses of Effexor XR during the premarketing assessment for each approved indication is shown in Table 8.
The extent to which the finding of an increased risk of fatal outcomes can be attributed to the toxicity of venlafaxine in overdosage, as opposed to some characteristic s of venlafaxine-treated patients, is not clear.
When will I feel better?
It might be best to stop driving and cycling for the first few days of treatment until you know how this medicine makes you feel.
Your doctor will advise you on how you should gradually discontinue Venlafaxine treatment.
This Medication Guide does not take the place of talking to your healthcare provider about your medical condition or treatment.
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Do not start or stop taking any medicines, including those bought without a prescription, natural and herbal remedies, before checking with your doctor or pharmacist.
It is important to talk with your healthcare provider about the risks of treating depression and also the risks of not treating it.
Do not give this medicine to anyone younger than 18 years old without the advice of a doctor.
Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction with antidepressants compared to placebo in adults aged 65 and older.
A meta analysis of 21 clinical trials of venlafaxine for the treatment of depression in adults found that compared to placebo, venlafaxine reduced the risk of suicidal thoughts and behavior.
This may increase the levels of venlafaxine in your body.
You can eat and drink normally while taking venlafaxine.
Some rarely used antidepressants can interact with venlafaxine to cause very high blood pressure even when they have been stopped for a few weeks.
Etoperidone Nefazodone Trazodone.
Do not use Effexor within 7 days before or 14 days after you have used a MAO inhibitor , such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
These include:.
Urgent advice: Contact a doctor straight away if:.
Do not stop taking your medicine unless your doctor tells you to.
Archived from the original on 21 August
This group of medicines is used to treat depression and other conditions such as anxiety disorders.
Venlafaxine is an antidepressant belonging to a group of drugs called selective serotonin and norepinephrine reuptake inhibitors SSNRIs.
Efficacy was assessed on the basis of outcomes in three variables: 1 percentage of patients free of full-symptom panic attacks on the Panic and Anticipatory Anxiety Scale PAAS ; 2 mean change from baseline to endpoint on the Panic Disorder Severity Scale PDSS total score; and 3 percentage of patients rated as responders much improved or very much improved on the Clinical Global Impressions CGI Improvement scale.
There may be circumstances when it is necessary to initiate treatment with a MAOI such as linezolid or intravenous methylene blue in a patient taking Effexor XR.
It consists of two enantiomers present in equal quantities termed a racemic mixture , both of which have the empirical formula of C 17 H 27 NO 2.
But if your symptoms are severe, call or go to the nearest emergency room right away.
This usually happens within the first few months of treatment or during dosage changes.
Some people might find they gain weight.
Symptoms of depression can vary from sadness to fatigue.
Possible side effects 5.
Symptoms such as these may be associated with an increased risk for suicidal thinking and behavior and indicate a need for very close monitoring [see Boxed Warning and Warnings and Precautions 5.
The good effects of venlafaxine may, after a while, improve your sex life as your mood lifts and you become interested in life and relationships again.
If Venlafaxine Tablets are stopped suddenly or the dose is reduced too quickly, some SAME SIZE ARTWORK mm x mm patients may experience symptoms such as tiredness, dizziness, light-headedness, headache, sleeplessness, nightmares, dry mouth, loss of appetite, feeling or being sick, diarrhoea, nervousness, agitation, confusion, tinnitus ringing in the ears , tingling or rarely electric shock sensations, weakness, sweating, seizures, or flu-like symptoms.
O-desmethylvenlafaxine ODV , the major human metabolite of venlafaxine, administered by oral gavage to mice and rats for 2 years did not increase the incidence of tumors in either study.
The use of psychotropic drugs that interfere with serotonin reuptake is associated with the occurrence of upper gastrointestinal bleeding and concurrent use of an NSAID or aspirin may potentiate this risk of bleeding [see Warnings and Precautions 5.
Never take 2 doses at the same time to make up for a forgotten one.
All patients recovered.
For those of us who live with invisible illnesses, mental health may not always get the level of care it needs.
Common Adverse Reactions in Placebo-controlled Studies.
There are few well-controlled studies of venlafaxine in pregnant women.
Prescriptions for Effexor XR should be written for the smallest quantity of capsules consistent with good patient management, in order to reduce the risk of overdose.
This can be harmful or prevent the drug from working well.
Administration of activated charcoal can prevent absorption of the drug.
Reported symptoms include agitation, anorexia, anxiety, confusion, impaired coordination and balance, diarrhea, dizziness, dry mouth, dysphoric mood, fasciculation, fatigue, flu-like symptoms, headaches, hypomania, insomnia, nausea, nervousness, nightmares, sensory disturbances including shock-like electrical sensations , somnolence, sweating, tremor, vertigo, and vomiting.
Current Drug Delivery.
Venlafaxine passes into breast milk.
If these effects are mild, they may go away within a few days or a couple of weeks.
Subsequently, the physician may continue decreasing the dose, but at a more gradual rate [see Dosage and Administration 2.
It may also help if you avoid rich or spicy food.
Patients should be advised that taking Effexor XR can cause mild pupillary dilation, which in susceptible individuals, can lead to an episode of angle closure glaucoma.
To make the extended-release Effexor XR capsule easier to swallow, you may open the capsule and sprinkle the medicine into a small amount of applesauce.
Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Effexor XR is a prescription medicine used to treat depression.
Because of the potential for serious adverse reactions in nursing infants from Effexor XR, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Important considerations for taking venlafaxine.
When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.
Patients should be cautioned about the concomitant use of Effexor XR and NSAIDs, aspirin, warfarin, or other drugs that affect coagulation since combined use of psychotropic drugs that interfere with serotonin reuptake and these agents has been associated with an increased risk of bleeding [see Warnings and Precautions 5.
Is it safe to take it for a long time?
There was considerable variation in risk of suicidality among drugs, but a tendency toward an increase in the younger patients for almost all drugs studied.
Starting Effexor XR in a patient who is being treated with an MAOI such as linezolid or intravenous methylene blue is also contraindicated, because of an increased risk of serotonin syndrome [see Dosage and Administration 2.
Take the missed dose as soon as you remember.
Do not drive or use tools or machines if you feel dizzy or if you just feel a bit shaky.
The mean dose in completers was mg per day study 3.
You should not take venlafaxine if you have uncontrolled narrow-angle glaucoma , or if you are being treated with methylene blue injection.
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For this drug to work well, a certain amount needs to be in your body at all times.
Because there was much individual variability in clearance between patients with renal impairment, individualization of dosage may be desirable in some patients [see Use in Specific Populations 8.
See also: List of adverse effects of venlafaxine.
If it carries on, tell your doctor.
A second 8-week study evaluating doses of 75 and mg per day and placebo showed that both doses were more effective than placebo on some of these same outcomes; however, the 75 mg per day dose was more consistently effective than the mg per day dose study 2.
Effexor XR contains spheroids, which release the drug slowly into the digestive tract.
Generic Name: venlafaxine hydrochloride Dosage Form: capsule, extended release.
If you are taking this medicine during pregnancy, other symptoms your baby might have when it is born is not feeding properly, in addition to having trouble breathing.
The recommended dose is 75 mg per day, administered in a single dose.
However, greater sensitivity of some older individuals cannot be ruled out.
The safety of Effexor XR treatment for pediatric patients has not been systematically assessed for chronic treatment longer than six months in duration.
For people with hyperthyroidism: Hyperthyroidism can increase your heart rate.
You will usually take 75mg extended release tablets or capsules once a day.
Provide supportive and symptomatic measures.
This raises your risk of side effects.
Related: Autism spectrum disorder.
Caution patients about the risk of bleeding associated with the concomitant use of Effexor XR and NSAIDs, aspirin, or other drugs that affect coagulation.
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Are there other treatments that will help?
Venlafaxine oral tablet may cause drowsiness.
Call your doctor right away if you become pregnant while taking this drug.
At least 14 days should elapse between discontinuation of an MAOI intended to treat psychiatric disorders and initiation of therapy with Effexor XR.
Your reactions could be impaired.
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These measures will help protect the environment.
Effexor XR and some medicines may interact with each other, may not work as well, or may cause serious side effects.
These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer.
Do not take this medicine in larger or smaller amounts or for longer than recommended.
Do not take extra medicine to make up the missed dose.
Get emergency medical help if you have signs of an allergic reaction to venlafaxine: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
However, in rats, there was a decrease in pup weight, an increase in stillborn pups, and an increase in pup deaths during the first 5 days of lactation, when dosing began during pregnancy and continued until weaning.
What should I tell my healthcare provider before taking Effexor XR?
How will it make me feel?
Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
A lack of motivation may be caused by depression, or it may be caused by something else.
Is venlafaxine better than other antidepressants?
It should be noted that, while the maximum recommended dose for moderately depressed outpatients is also mg per day for Effexor immediate-release , more severely depressed inpatients in one study of the development program for that product responded to a mean dose of mg per day range of to mg per day.
People with liver problems: People with mild to moderate liver problems should take about half of the typical dose.
If you have an allergic reaction, call your doctor or local poison control center right away.
No significant QT prolongation effect of venlafaxine mg was detected.
Effexor drug interactions in more detail.
This could result in dangerous side effects.
Want to supplement your seasonal depression treatment?
Effexor is not approved for use in children.
The risk differences drug versus placebo , however, were relatively stable within age strata and across indications.
Venlafaxine dosage information in more detail.
Somnolence was the most commonly reported symptom.
The majority of the reports involved ingestion in which the total dose of venlafaxine taken was estimated to be no more than several-fold higher than the usual therapeutic dose.
See also: Effexor dosage information in more detail.
The patients taking venlafaxine had significantly higher risk of completed suicide than the ones on fluoxetine or citalopram Celexa.
If concomitant treatment with Effexor XR and these drugs is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases.
Patients receiving warfarin therapy should be carefully monitored when Effexor XR is initiated or discontinued.
An insufficient number of patients received mean doses of Effexor XR over mg per day in clinical studies to fully evaluate the incidence of sustained increases in blood pressure at these higher doses.
Figure 1: Effect of interacting drugs on the pharmacokinetics of venlafaxine and active metabolite O-desmethylvenlafaxine ODV.

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Venlafaxine was not found to have any significant CNS stimulant activity in rodents.
Information from clinical trials has shown an increased risk of suicidal behaviour in young adults less than 25 years old with psychiatric conditions who were treated with an antidepressant.
Treatment should consist of those general measures employed in the management of overdosage with any drug.
For some patients, it may be desirable to start at
However, the 75 and mg per day doses were not as consistently effective as the highest dose study 1.
Package leaflet: Information for the user Venlafaxine
Abrupt discontinuation or dose reduction of venlafaxine at various doses has been found to be associated with the appearance of new symptoms, the frequency of which increased with increased dose level and with longer duration of treatment.
UK Edition.
However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages.
Efficacy was established in two 8-week and two week placebo-controlled trials.
These benefits with respect to pain were reversed with naloxone , an opioid antagonist, thus supporting an opiate mechanism.
Electrocardiogram changes e.
Effexor XR.
There was no evidence for any greater effectiveness of the to mg per day group compared to the 75 mg per day group in the 6-month study.
Older adults may be at higher risk than younger people for low sodium levels in their blood when taking venlafaxine.
Ask if you are not sure.
Even a single missed dose can result in withdrawal symptoms.
Symptoms include:.
Therapeutic effects are usually achieved within 3 to 4 weeks.
The other ingredients are lactose, microcrystalline cellulose, sodium starch glycollate, pregelatinised starch, magnesium stearate, yellow iron oxide E and red iron oxide E
Elderly people may be at greater risk for this.
These include: dizziness feeling sick numbness or tingling in the hands or feet trouble sleeping feeling agitated or anxious headaches shaking.
The expiry date refers to the last day of that month.
Effexor venlafaxine is an antidepressant belonging to a group of drugs called selective serotonin and norepinephrine reuptake inhibitors SSNRIs.
You should not take Effexor if you have uncontrolled narrow-angle glaucoma , or if you are being treated with methylene blue injection.
Take Effexor exactly as prescribed by your doctor.
The symptoms of a possible overdose may include a rapid heart beat, changes in level of alertness ranging from sleepiness to coma , blurred vision, seizures or fits, and vomiting.
If you often forget doses, it may help to set an alarm to remind you.
Report any new or worsening symptoms to your doctor, such as: mood or behavioral changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physically , more depressed, or have thoughts about suicide or hurting yourself.
Others: A Amoxapine Antihistamines e.
It should be noted, that in some cases the clinical picture is consistent with serotonin syndrome [see Warnings and Precautions 5.
Follow all directions on your prescription label.
Across most indications, a dose-related increase in mean supine systolic and diastolic blood pressure was evident in patients treated with Effexor XRs.
The conditions and duration of exposure to venlafaxine in all development programs varied greatly, and included in overlapping categories open and double-blind studies, uncontrolled and controlled studies, inpatient Effexor only and outpatient studies, fixed-dose, and titration studies.
Patients received fixed doses of 75 or mg per day in one study study 1 and 75 or mg per day in the other study study 2.
You may find it helpful to tell a friend or relative that you are depressed, and that you have been prescribed this medication; it might be useful to show them this leaflet.
The adverse reaction profile did not differ substantially between the different patient populations.
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Venlafaxine is neither recommended nor approved for the treatment of major depressive episodes in bipolar disorder as it can induce mania or mixed episodes.
The following adverse reactions are discussed in greater detail in other sections of the label:.
Stay alert to changes in your mood or symptoms.
You may ask your healthcare provider or pharmacist for information about Effexor XR that is written for healthcare professionals.
If you have liver or kidney problems, talk to your doctor, as your dose may need to be different.
Your doctor can tell you more.
Renal elimination of venlafaxine and its metabolites is thus the primary route of excretion.
Decreases Compared to Placebo.
Do not drink alcohol with venlafaxine.
Hidden categories: Articles with incomplete citations from November All articles lacking reliable references Articles lacking reliable references from December Use dmy dates from December Template:drugs.
The amount of venlafaxine that can lead to an overdose varies from person to person.
Check with your doctor or pharmacist if you are not sure.
Cardiovascular system — Postural hypotension, syncope, hypotension, tachycardia.
Venlafaxine helps many people recover from depression, and has fewer unwanted side effects than older antidepressants.
This Medication Guide has been approved by the U.
Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
In a clinical study for PD, patients continuing Effexor XR at the same dose at which they responded during the initial 12 weeks of treatment experienced a statistically significantly longer time to relapse than patients randomized to placebo [see Clinical Studies
Common side effects These side effects happen in more than 1 in people.
Patients should be informed that the active medication has already been absorbed by the time the patient sees the spheroids.
Venlafaxine Images.
Here are nine warning signs to look for if you think you might be depressed.
Venlafaxine is well absorbed and extensively metabolized in the liver.
If you have these thoughts at any time, tell your doctor or go to a hospital straight away.
Amoxapine Maprotiline Mianserin Mirtazapine Setiptiline.
You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour.
Individualization of tapering may be necessary [see Warnings and Precautions 5.
If you become pregnant while taking venlafaxine speak to your doctor.
In general, the adverse reaction profile of venlafaxine in placebo-controlled clinical studies in children and adolescents ages 6 to 17 was similar to that seen for adults.
Patients treated with Effexor immediate release for at least 3 months in placebo-controlled month extension trials had a mean final on-therapy increase in total cholesterol of 9.
Venlafaxine is not FDA approved for use in children.
There was no evidence that higher doses confer any additional benefit.
Ensure an adequate airway, oxygenation, and ventilation.
IUPAC name.
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The frontal cortex largely lacks dopamine transporters, therefore venlafaxine can increase dopamine neurotransmission in this part of the brain.
For most people, venlafaxine is safe to take for a long time.
This can cause more side effects.
Venlafaxine was similar in efficacy to the atypical antidepressant bupropion ; however, the remission rate was lower for venlafaxine.
The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including Effexor XR alone, but particularly with concomitant use of other serotonergic drugs including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St.
Speak to your doctor if you are worried.
Venlafaxine can make you feel less hungry than usual, so you may lose weight when you start taking it.
Therefore, your doctor may wish to do blood tests occasionally, particularly if you have been taking Venlafaxine for a long time.
Do not take these drugs with venlafaxine.
Do not stop using Effexor without first talking to your doctor.
This includes aspirin, ibuprofen Advil, Motrin , naproxen Aleve , celecoxib Celebrex , diclofenac, indomethacin, meloxicam, and others.
A study released in May by the Canadian Medical Association Journal suggests use of venlafaxine doubles the risk of miscarriage.
This results in a lower peak plasma concentration.
Can I drink alcohol with it?
The most commonly reported events in overdosage include tachycardia, changes in level of consciousness ranging from somnolence to coma , mydriasis, seizures, and vomiting.
Serotonin-norepinephrine reuptake inhibitors.
Such patients should undergo a prompt medical evaluation, and discontinuation of venlafaxine therapy should be considered.
You should not drive, use heavy machinery, or do things that require you to be alert until you know you can function normally.
Start with your plate.
Do not use Effexor within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
FDA warning: Suicidal behavior warning This drug has a black box warning.
There have been false positives reported for phencyclidine PCP , cocaine and amphetamine with routine urine-based drug tests.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Do not chew an extended-release capsule.
Inactive Ingredients.
Open-angle glaucoma is not a risk factor for angle closure glaucoma.
Patients may wish to be examined to determine whether they are susceptible to angle closure, and have a prophylactic procedure e.
How to store Venlafaxine Tablets 6.
Serotonin release by platelets plays an important role in hemostasis.
If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered.
Swallow all of the mixture without chewing, and do not save any for later use.
How much to take The usual starting dose of venlafaxine is 75mg a day.
Effexor XR treatment for up to 12 weeks and up to 6 months in premarketing placebo-controlled Social Anxiety Disorder trials was associated with mean final on-therapy increases in serum cholesterol concentration of approximately 7.
Effexor may cause serious lung problems in a newborn if the mother takes the medicine late in pregnancy during the third trimester.
Venlafaxine Tablets
It is generally agreed that acute episodes of MDD require several months or longer of sustained pharmacological therapy beyond response to the acute episode.
To make the extended-release capsule easier to swallow, you may open the capsule and sprinkle the medicine into a small amount of applesauce.
Venlafaxine may cause a sensation of restlessness or an inability to sit or stand still during the first few weeks of treatment.
About venlafaxine Venlafaxine is a type of antidepressant often used to treat depression.
You should not drive, operate heavy machinery, or do other dangerous activities until you know how Effexor XR affects you.
Venlafaxine is a treatment for adults with depression.
Not all possible interactions are listed here.
Important Tell your doctor or pharmacist if you are taking any other medicines, including herbal remedies, vitamins or supplements.
Each capsule should be swallowed whole with fluid and not divided, crushed, chewed, or placed in water or it may be administered by carefully opening the capsule and sprinkling the entire contents on a spoonful of applesauce.
Venlafaxine belongs to a class of antidepressant drugs called serotonin norepinephrine reuptake inhibitors SNRIs.
However, individual dosage adjustments may be necessary.
Advise families and caregivers of the need for close observation and communication with the prescriber [see Warnings and Precautions 5.
How to take Venlafaxine Tablets 4.
More rarely, Venlafaxine may reduce the function of platelets in your blood, leading to an increased risk of bruising or bleeding.
However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.

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Take Venlafaxine tablets at approximately the same time each day, in the morning and in the evening, with food.
Check with your doctor before starting to take venlafaxine if you: have had an allergic reaction to venlafaxine or any other medicines in the past have a heart problem - as venlafaxine can speed up or change your heartbeat are trying to become pregnant, are already pregnant or you are breastfeeding have an eye problem called glaucoma because venlafaxine can increase the pressure in your eye have epilepsy or are having electroconvulsive treatment - venlafaxine may increase your risk of having a seizure If you have diabetes , venlafaxine can make it more difficult to keep your blood sugar stable.
If you have a seizure, stop taking venlafaxine and call your doctor right away.
It can be potentially dangerous to take venlafaxine with:.
These are not all the possible side effects of Effexor XR.
Patients should be advised of the following issues and should be asked to alert their prescriber if these occur while taking Effexor XR.
Cannabis can also make drowsiness worse with venlafaxine, especially in people who have just started taking it.
SNRIs work by increasing the levels of substances called serotonin and norepinephrine in your brain.
Venlafaxine may interact with other medications.
The need for continuing medication in patients with PD who improve with Effexor XR treatment should be periodically reassessed.
If you take Effexor XR , you should not take any other medicines that contain venlafaxine including: venlafaxine HCl.
Irreversible: Selegiline.
The pooled analyses of placebo-controlled studies in children and adolescents with MDD, Obsessive Compulsive Disorder OCD , or other psychiatric disorders included a total of 24 short-term studies of 9 antidepressant drugs in over 4, patients.
Venlafaxine can be taken by adults for depression, anxiety and panic attacks.
Your dosage, drug form, and how often you take the drug will depend on:.
Talk to you doctor before using this drug if breastfeeding.
Your doctor may start you on a low dosage and monitor you closely if they increase your dosage.
These side effects happen in more than 1 in people.
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Depressed patients who are currently being treated at a therapeutic dose with Effexor immediate release may be switched to Effexor XR at the nearest equivalent dose mg per day , e.
In clinical studies with Effexor XR, tapering was achieved by reducing the daily dose by 75 mg at one-week intervals.
Some medicines and venlafaxine can interfere with each other and increase the chances of you having side effects.
While venlafaxine has not been systematically studied in clinical studies for its potential for abuse, there was no indication of drug-seeking behavior in the clinical studies.
You should use Venlafaxine only after discussing the potential benefits and the potential risks to your unborn child with your doctor.
If you forget to take Venlafaxine Tablets If you miss a dose, take it as soon as you remember.
Psychiatry On-line.
Suicide is a known risk of depression and certain other psychiatric disorders, and these disorders themselves are the strongest predictors of suicide.
One patient who ingested 2.
In placebo-controlled premarketing studies, there were increases in mean blood pressure see Table
Read this next.
Talk to your doctor about other drug options that may work for you.
Use caution in treating patients with pre-existing hypertension or cardiovascular or cerebrovascular conditions that might be compromised by increases in blood pressure.
When used with venlafaxine, these drugs can cause dangerous effects in your body.
Reporting of side effects If you get any side effects, talk to your doctor or pharmacist.
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure:.
Reported clinical findings have included respiratory distress, cyanosis, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hypertonia, hyperreflexia, tremor, jitteriness, irritability, and constant crying.
If your doctor has prescribed Venlafaxine for a patient under 18 and you want to discuss this, please go back to your doctor.
Get emergency medical help if you have signs of an allergic reaction to Effexor: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
While these events are generally self-limiting, there have been reports of serious discontinuation symptoms.
Patients receiving continued Effexor XR treatment experienced statistically significantly lower relapse rates over the subsequent 26 weeks compared with those receiving placebo study 4.
Read the Medication Guide that comes with Effexor XR before you start taking it and each time you get a refill.
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Venlafaxine was originally marketed as Effexor in most of the world; generic venlafaxine has been available since around and extended release venlaxafine has been available since around
Effexor XR treatment for up to 8 weeks and up to 6 months in premarketing placebo-controlled GAD trials was associated with mean final on-therapy increases in serum cholesterol concentration of approximately 1.
You may see an improvement in your symptoms after a week although it usually takes between 4 and 6 weeks before you feel the full benefits.
Effexor XR and other antidepressant medicines may cause serious side effects, including:.
Similar improvement was observed in both groups.
Efficacy was established in four week and one week, placebo-controlled trials.
Contents of the pack and other information 1.
Venlafaxine may increase suicidal thoughts or actions in some children and young adults.
These effects can increase the pressure in your eyes.
If needed, your doctor may increase the dose gradually up to a maximum of mg daily.
If you have problems with your liver or kidneys your doctor might prescribe a lower dose.
No reports involved the administration of methylene blue by other routes such as oral tablets or local tissue injection or at lower doses.
Ask your doctor before taking a nonsteroidal anti-inflammatory drug NSAID for pain, arthritis, fever, or swelling.
Tell your doctor right away if you become pregnant while taking Effexor.
These risk differences drug-placebo difference in the number of cases of suicidality per 1, patients treated are provided in Table 1.
It is important to continue taking venlafaxine to keep you well.
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
There may be new information.
You may need to decide whether to stop breastfeeding or stop taking this medication.
For children: This drug should not be used in people younger than 18 years of age.
There were suicides in the adult studies, but the number was not sufficient to reach any conclusion about drug effect on suicide.
The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
Also you must wait at least one week after you stop taking Venlafaxine tablets before you can take an MAOI.
Treating depression properly is important to help you get better.
Amiodarone Amphetamines e.
The cause of these deaths is not known.
However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects.
The use of Effexor XR within 14 days of discontinuing treatment with an MAOI intended to treat psychiatric disorders is also contraindicated [see Dosage and Administration 2.
Figure 3: Pharmacokinetics of venlafaxine and its metabolite O-desmethylvenlafaxine ODV in special populations.
A black box warning alerts doctors and patients about drug effects that may be dangerous.
Call your healthcare provider right away if you have any of the following symptoms, or call if an emergency.
In primate drug discrimination studies, venlafaxine showed no significant stimulant or depressant abuse liability.
You will usually take
SSRIs and SNRIs, including Effexor XR, may increase the risk of bleeding events, ranging from ecchymoses, hematomas, epistaxis, petechiae, and gastrointestinal hemorrhage to life-threatening hemorrhage.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.
The higher risk and increased severity of discontinuation syndrome symptoms relative to other antidepressants may be related to the short half-life of venlafaxine and its active metabolite.
Symptoms of an overdose of this drug can include:.
Call your doctor right away if you have serious side effects.
Call your doctor for medical advice about side effects.
Effexor XR should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The concomitant use of Effexor XR with tryptophan supplements is not recommended [see Dosage and Administration 2.
These are warning signs of a serious allergic reaction.
Should the decision be made to treat a pediatric patient with Effexor XR, regular monitoring of weight and height is recommended during treatment, particularly if treatment is to be continued long-term [see Warnings and Precautions 5.
Some doctors may prescribe venlafaxine off label for the treatment of diabetic neuropathy in a similar manner to duloxetine and migraine prophylaxis in some people, however, venlafaxine can exacerbate or cause migraines.
The effect of venlafaxine on the QT interval was evaluated in a randomized, double-blind, placebo- and positive-controlled three-period crossover thorough QT study in 54 healthy adult subjects.
Serotonin syndrome symptoms may include mental status changes e.
Venlafaxine , sold under the brand name Effexor among others, is an antidepressant medication of the serotonin-norepinephrine reuptake inhibitor SNRI class.
In addition, at least 7 days should be allowed after stopping Effexor XR before starting an MAOI intended to treat psychiatric disorders [see Contraindications 4.
Signs and symptoms of NMS may include a combination of fever, fast heart beat, sweating, severe muscle stiffness, confusion, increased muscle enzymes determined by a blood test.
Patients not responding to the initial 75 mg per day dose may benefit from dose increases to a maximum of mg per day.
However, you may have a relapse of depression if you stop taking your antidepressant.
Effexor Images.
Venlafaxine is usually categorized as a serotonin-norepinephrine reuptake inhibitor SNRI , but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor SNDRI.
Studies have shown that the extended release formula has a lower incidence of nausea as a side effect, resulting in better compliance.
No suicides occurred in any of the pediatric studies.
Having more serotonin and norepinephrine in your brain can improve your symptoms of depression and anxiety.
The usual starting dose of venlafaxine is 75mg a day.
Talk to your doctor if they last longer than a week or are severe.
Headaches should usually go away after the first week of taking venlafaxine.
Capsules contain venlafaxine hydrochloride equivalent to
Not every pharmacy stocks this drug.
This is due to lack of specificity of the screening tests.
Consequently, the precautions for adults apply to pediatric patients [see Warnings and Precautions 5.
A comparative meta-analysis of 21 major antidepressants found that venlafaxine, agomelatine , amitriptyline , escitalopram , mirtazapine , paroxetine , and vortioxetine were more effective than other antidepressants although the quality of many comparisons was assessed as low or very low.
Venlafaxine may cause serious lung problems in a newborn if the mother takes the medicine late in pregnancy during the third trimester.
It may also affect your ability to make decisions, think clearly, or react quickly.
At baseline, patients prescribed venlafaxine had a greater number of risk factors for suicide such as prior suicide attempts than patients treated with other anti-depressants.
Examination of subsets of the population studied did not reveal any differential responsiveness on the basis of gender.
Talk with your healthcare provider if there is something you do not understand or want to learn more about.
Therefore, you should take special care with your dental hygiene.
Generic drugs usually cost less than brand-name drugs.
Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies.
Signs of Depression.
Pre-existing glaucoma is almost always open-angle glaucoma because angle closure glaucoma, when diagnosed, can be treated definitively with iridectomy.
You may need to read it again.
Tell your doctor immediately, or go to the casualty department at your nearest hospital if you think serotonin syndrome is happening to you.
Venlafaxine is a substrate of P-glycoprotein P-gp , which pumps it out of the brain.
Venlafaxine and ODV have been reported to be excreted in human milk.
Interactive image.
Your doctor will need to check your progress at regular visits while you are using venlafaxine.
See also: Venlafaxine dosage information in more detail.
Food and Drug Administration for all antidepressants.
Administration of Effexor XR mg once daily generally resulted in lower C max and later T max values than for Effexor immediate release administered twice daily Table
February
Advise patients to notify their physician if they develop allergic phenomena such as rash, hives, swelling, or difficulty breathing.
How do I come off venlafaxine?
Dosage adjustment based on the age or gender of a patient is generally not necessary [see Dosage and Administration 2.
Some may be better suited for you than others.
Venlafaxine Tablets 75 mg and
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This drug should only be used if the potential benefit justifies the potential risk to the fetus.
If you remember just a few hours before your next scheduled dose, take only one dose.
See also: Venlafaxine drug interactions in more detail.
You may find it helpful to tell a relative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet.
The primary route of excretion of venlafaxine and its metabolites is via the kidneys.
People with severe liver disease or cirrhosis may need an even lower dosage.
People who are on dialysis should take half of the typical dosage.
In these two studies, Effexor XR was statistically significantly more effective than placebo for each fixed dose on all three endpoints, but a dose-response relationship was not clearly established.
Effexor XR may be associated with these serious side effects :.
People stopping venlafaxine commonly experience discontinuation symptoms such as dysphoria , headaches , nausea , irritability , emotional lability , sensation of electric shocks, and sleep disturbance.
A few people may get sexual side effects, such as problems getting an erection or a lower sex drive.
Effexor reviews.
Swallow it whole.
The following symptoms, anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia psychomotor restlessness , hypomania, and mania, have been reported in adult and pediatric patients being treated with antidepressants for MDD, as well as for other indications, both psychiatric and nonpsychiatric.
Venlafaxine drug interactions in more detail.
During marketing of Effexor XR, other SNRIs, and SSRIs, there have been spontaneous reports of adverse events occurring upon discontinuation of these drugs, particularly when abrupt, including the following: dysphoric mood, irritability, agitation, dizziness, sensory disturbances e.
If your symptoms are severe, call or go to the nearest emergency room.
Drug Safety.
The extended release controlled release version distributes the release of the drug into the gastrointestinal tract over a longer period than normal venlafaxine.
Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Venlafaxine warnings.
Discontinuation symptoms have been systematically evaluated in patients taking venlafaxine, including prospective analyses of clinical studies in GAD and retrospective surveys of studies in MDD and SAD.
The pupillary dilation that occurs following use of many antidepressant drugs including Effexor XR may trigger an angle closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy.
Give a list of all your medicines to any healthcare provider who treats you.
The complete text of the Medication Guide is reprinted at the end of this document.
An analysis of clinical trials by the FDA statisticians showed the incidence of suicidal behaviour among the adults on venlafaxine to be not significantly different from fluoxetine or placebo.
Your doctor will need to check your progress at regular visits while you are using Effexor.
For more information, ask your healthcare provider or pharmacist.
If acceptable alternatives to linezolid or intravenous methylene blue are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patient, Effexor XR should be stopped promptly, and linezolid or intravenous methylene blue can be administered.
Serious side effects and their symptoms can include the following:.
These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older [see Warnings and Precautions 5.
Non- clinical studies have demonstrated that venlafaxine and its active metabolite, ODV, are potent and selective inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake.
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The pooled analyses of placebo-controlled studies in adults with MDD or other psychiatric disorders included a total of short-term studies median duration of 2 months of 11 antidepressant drugs in over 77, patients.
They may want to review your treatment.
Academic Press.
Talk to your doctor if you think you might take any while taking venlafaxine.
From Wikipedia, the free encyclopedia.
Drug Status Rx.
Give the medicine at least 6 weeks to work.
Venlafaxine may impair your thinking or reactions.
Symptoms may include:.
This may be the result of a blood disorder which leads to an increased risk of infection.
How to take Venlafaxine Tablets Always take this medicine exactly as your doctor has told you.
The risk of using venlafaxine in combination with other CNS-active drugs has not been systematically evaluated.
There is no specific antidote for venlafaxine, and management is generally supportive, providing treatment for the immediate symptoms.
Drug release is controlled by diffusion through the coating membrane on the spheroids and is not pH-dependent.
Skin and appendages — Urticaria, pruritus, rash, alopecia.
If it is not treated, your condition may not go away and may become more serious and more difficult to treat.
The possibility of these adverse events should be considered in venlafaxine-treated patients who present with progressive dyspnea, cough or chest discomfort.
According to the FDA analysis of clinical trials [24] venlafaxine caused a statistically significant 5-fold increase in suicidal ideation and behaviour in persons younger than
In both studies, Effexor XR demonstrated superiority over placebo on the primary efficacy measure defined as change from baseline in the HAM-D total score to the endpoint visit, Effexor XR also demonstrated superiority over placebo on the key secondary efficacy endpoint, the Clinical Global Impressions CGI Severity of Illness scale.
Therapy with Effexor XR can be resumed 24 hours after the last dose of linezolid or intravenous methylene blue [see Warnings and Precautions 5.
Eur equivalent to Venlafaxine
It might be best to stop drinking alcohol during the first few days of treatment until you see how this medicine affects you.
Dose increases should be in increments of up to 75 mg per day, as needed, and should be made at intervals of not less than 7 days.
It is not known whether or not the dose of Effexor XR needed for maintenance treatment is identical to the dose needed to achieve an initial response.
Special senses — Angle-closure glaucoma [see Warnings and Precautions 5.
Additionally, in high doses it weakly inhibits the reuptake of dopamine , [56] with recent evidence showing that the norepinephrine transporter also transports some dopamine as well, since dopamine is inactivated by norepinephrine reuptake in the frontal cortex.
Some of the common side effects of venlafaxine will gradually improve as your body gets used to it.
Effexor XR is not indicated for weight loss alone or in combination with other products.
Do not stop using venlafaxine without first talking to your doctor.
In most cases, no signs or symptoms were associated with overdose.
After adjusting for known risk factors, venlafaxine was associated with an increased risk of suicide relative to fluoxetine and dothiepin that was not statistically significant.
Interstitial lung disease and eosinophilic pneumonia associated with venlafaxine therapy have been rarely reported.

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