By reporting side effects you can help provide more information on the safety of this medicine.
Venlafaxine oral tablet is used to treat depression immediate-release tablet and extended-release tablet.
Do not use Effexor XR for a condition for which it was not prescribed.
No accumulation of venlafaxine has been observed during chronic administration in healthy subjects.
Your healthcare provider or pharmacist can tell you if it is safe to take Effexor XR with your other medicines.
A statistically significant greater risk for attempted suicide remained after adjustment, but the authors concluded that it could be due to residual confounding.
Effexor XR Images.
When taken during pregnancy, similar drugs SSRIs may increase the risk of a serious condition in babies, called persistent pulmonary hypertension of the new born PPHN , making the baby breathe faster and appear bluish.
Venlafaxine tablets and capsules can be either immediate release or extended release.
Consult a Certified Poison Control Center for up-to-date guidance and advice or www.
It is unknown whether the suicidality risk extends to longer term use, i.
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Steady-state concentrations of venlafaxine and ODV in plasma are attained within 3 days of oral multiple-dose therapy.
Signs and symptoms of hyponatremia include headache, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which may lead to falls.
Skip the missed dose if it is almost time for your next scheduled dose.
Sexual side effects usually pass after the first couple of weeks.
Here are 8 photographs of what feelings of turmoil may look like.
Patients receiving continued Effexor treatment experienced statistically significantly lower relapse rates over the subsequent 52 weeks compared with those receiving placebo study 5.
Approval History FDA approved
At the same time, fluoxetine Prozac halved the suicide risk.
Epidemiological studies have shown that venlafaxine-treated patients have a higher preexisting burden of suicide risk factors than SSRI-treated patients.
If you have hyperthyroidism and take venlafaxine, your heart rate may increase to a dangerous level.
Canadian Journal of Psychiatry.
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Effexor side effects in more detail.
Venlafaxine will not affect contraception including the combined pill or emergency contraception.
Cardiovascular system — QT prolongation, ventricular fibrillation, ventricular tachycardia including torsade de pointes , takotsubo cardiomyopathy.
See also: Effexor drug interactions in more detail.
Do not stop venlafaxine without talking to your doctor.
It can be potentially dangerous to take venlafaxine with: stimulants like MDMA ecstasy or cocaine hallucinogens like LSD novel psychoactive substances which used to be known as legal highs like mephedrone.
It may take several weeks before your symptoms improve.
It comes as tablets and capsules which are available only on prescription.
If you provide a urine sample for drug screening, tell the laboratory staff that you are taking this medicine.
It should not be used in conjunction with a monoamine oxidase inhibitor MAOI , as it can cause potentially fatal serotonin syndrome.
If the decision has been made to discontinue treatment, medication should be tapered, as rapidly as is feasible, but with recognition that abrupt discontinuation can be associated with certain symptoms [see Warnings and Precautions 5.
Some people feel worse during the first few weeks of treatment before they begin to feel better.
You must tell your doctor if you are taking medicines that can affect your heart rhythm.
You can take supplements to increase your serotonin levels.
You are especially at risk if you take venlafaxine doses greater than mg per day.
Adjunctive therapies Atypical antipsychotics aripiprazole , brexpiprazole , lurasidone , olanzapine , quetiapine , risperidone Buspirone Lithium lithium carbonate , lithium citrate Thyroid hormones triiodothyronine T 3 , levothyroxine T 4.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Figure 2: Effect of venlafaxine on the pharmacokinetics interacting drugs and their active metabolites.
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Venlafaxine may be used as part of a combination therapy.
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The structural formula is shown as follows:.
If this happens, your doctor may have you start taking venlafaxine again and decrease your dosage slowly.
Immediate release tablets release the venlafaxine into your system as soon as you swallow them.
Effexor XR was associated with mean final on-therapy increases in fasting serum triglycerides compared with placebo in premarketing clinical studies of SAD and PD up to 12 weeks pooled data and 6 months duration Table
Ask your doctor before making any changes in how or when you take your medications.
Venlafaxine and ODV exhibited linear kinetics over the dose range of 75 to mg per day.
Seizures have occurred with venlafaxine therapy.
Plasma levels of the O-desmethyl metabolite ODV were lower in rats than in patients receiving the maximum recommended dose.
Remember to take the packet with you, even if it is empty.
In controlled trials, there were dose-related increases in systolic and diastolic blood pressure, as well as cases of sustained hypertension [see Adverse Reactions 6.
The average change in body weight and incidence of weight loss percentage of patients who lost 3.
Do not stop Effexor XR without first talking to your healthcare provider.
The use of MAOIs intended to treat psychiatric disorders concomitantly with Effexor XR or within 7 days of discontinuing treatment with Effexor XR is contraindicated because of an increased risk of serotonin syndrome.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use venlafaxine only for the indication prescribed.
Your doctor will write the number of refills authorized on your prescription.
Common side effects include loss of appetite, constipation, dry mouth , dizziness, sweating, and sexual problems.
False positive test results may be expected for several days following discontinuation of venlafaxine therapy.
If any of the following happen, do not take more Venlafaxine.
Two 6-month studies, one evaluating Effexor XR doses of
Urogenital system — Urinary retention, urination impaired, urinary incontinence, urinary frequency increased, menstrual disorders associated with increased bleeding or increased irregular bleeding e.
My 6 Hidden Struggles of Depression When depression strikes, it can affect our mood and habits more than we realize.
Depression can make you less motivated to do things.
Ask your pharmacist to recommend a painkiller.
Discontinuation effects have been reported in patients receiving venlafaxine [see Dosage and Administration 2.
A class of drugs is a group of medications that work in a similar way.
Treatment with Effexor XR and any concomitant serotonergic agents should be discontinued immediately if the above events occur, and supportive symptomatic treatment should be initiated.
Venlafaxine oral tablet can interact with other medications, vitamins, or herbs you may be taking.
In reproductive developmental studies in rats and rabbits with O-desmethylvenlafaxine ODV , the major human metabolite of venlafaxine, evidence of teratogenicity was not observed at exposure margins of 13 in rats and 0.
For people with increased eye pressure glaucoma : Venlafaxine can widen your pupils and block the flow of fluid in your eye.
Ask your pharmacist how to throw away medicines you no longer use.
Do not drink too much alcohol.
Taking venlafaxine with certain medications raises your risk of side effects.
Talk to your doctor about breastfeeding your child.
Among the other reported symptoms were paresthesia of all four limbs, moderate dizziness, nausea, numb hands and feet, and hot-cold spells 5 days after the overdose.
The pharmacokinetics of venlafaxine and ODV are not substantially altered in the elderly [see Clinical Pharmacology
Urgent advice: Call your doctor straight away if:.
For a full list see the leaflet inside your medicines packet.
If concomitant use of Effexor XR with other serotonergic drugs e.
How to tell if the drug is working: The symptoms of your depression or anxiety should be less severe or happen less often.
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This is because the amount of these drugs in your body may be decreased.
Patients should be monitored for these symptoms when discontinuing treatment with Effexor XR.
Venlafaxine is used to treat major depressive disorder , anxiety and panic disorder.
Venlafaxine is an antidepressant that belongs to a group of medicines called serotonin and norepinephrine reuptake inhibitors SNRIs.
Advise patients that elevations in total cholesterol, LDL and triglycerides may occur and that measurement of serum lipids may be considered [see Warnings and Precautions 6.
What to do if you miss a dose: Take your dose as soon as you remember.
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Based on the mechanism of action of Effexor XR and the potential for serotonin syndrome, caution is advised when Effexor XR is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, SSRIs, other SNRIs, linezolid an antibiotic which is a reversible non-selective MAOI , lithium, tramadol, or St.
It is not common, but some people less than 1 in may have serious side effects when taking venlafaxine.
Driving and using machines Do not drive or use any tools or machines until you know how this medicine affects you.
Tell your doctor right away if you become pregnant while taking this medicine.
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Effexor XR is an extended-release capsule for once-a-day oral administration that contains venlafaxine hydrochloride, a serotonin and norepinephrine reuptake inhibitor SNRI.
Effexor XR can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly.
Venlafaxine oral tablet comes in immediate-release and extended-release forms.
Alpha-1 blockers e.
Your doctor will probably recommend reducing your dose gradually over several weeks - or longer, if you have been taking venlafaxine for a long time.
Effexor XR, like many antidepressants, should be used cautiously in patients with a history of seizures and should be discontinued in any patient who develops seizures.
Prescribers or other healthcare professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Effexor XR and should counsel them in its appropriate use.
Digestive system — Gastrointestinal hemorrhage [see Warnings and Precautions 5.
However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional.
Other brands: Effexor , Effexor XR.
Seizures are managed with benzodiazepines or other anticonvulsants.
If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital straight away.
These medicines are thought to work by increasing the levels of mood-enhancing chemicals called serotonin and noradrenaline in the brain.
Efficacy was established in three short-term 4, 8, and 12 weeks and two long-term, maintenance trials.
Never try to catch up by taking two doses at once.
The usual recommended starting dose is 75mg per day.
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Therefore, the dosage of your diabetes medicines may need to be adjusted.
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The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
There were differences in absolute risk of suicidality across the different indications, with the highest incidence in MDD.
However, if it is time for your next dose, skip the missed dose and take only a single dose as usual.
The originating document has been archived.
In patients of all ages who are started on antidepressant therapy monitor closely for clinical worsening and emergence of suicidal thoughts and behaviors.
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This may increase the risk of tooth decay dental caries.
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Families and caregivers of patients being treated with antidepressants for MDD or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of agitation, irritability, unusual changes in behavior, and the other symptoms described above, as well as the emergence of suicidality, and to report such symptoms immediately to healthcare providers.
Children and adolescents Venlafaxine should normally not be used for children and adolescents under 18 years.
For people with kidney disease: If you have kidney disease or a history of kidney disease, you may not be able to clear this drug from your body well.
Effexor XR should be administered in a single dose with food, either in the morning or in the evening at approximately the same time each day [see Clinical Pharmacology
No dose adjustment is recommended for the elderly on the basis of age alone, although other clinical circumstances, some of which may be more common in the elderly, such as renal or hepatic impairment, may warrant a dose reduction [see Dosage and Administration 2.
For seniors: The kidneys of older adults may not work as well as they used to.
In a longer term study study 3 , adult outpatients meeting DSM-IV criteria for PD who had responded during a week open phase with Effexor XR 75 to mg per day were randomly assigned to continue the same Effexor XR dose 75, , or mg or switch to placebo for observation for relapse under double-blind conditions.
Side effects such as feeling sick, headaches, sweating, and dry mouth are common.
There is a risk of an effect on the baby.
Some medicines can interact with venlafaxine and cause a serious condition called serotonin syndrome.
Atypical antipsychotics aripiprazole , brexpiprazole , lurasidone , olanzapine , quetiapine , risperidone Buspirone Lithium lithium carbonate , lithium citrate Thyroid hormones triiodothyronine T 3 , levothyroxine T 4.
Effexor XR should also not be started in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue.
Talk to your healthcare provider if you do not think that your condition is getting better with Effexor XR treatment.
Case reports and epidemiological studies case-control and cohort design have demonstrated an association between use of drugs that interfere with serotonin reuptake and the occurrence of gastrointestinal bleeding.
After you start treatment, you may feel worse before you feel better.
The efficacy of Effexor XR as a treatment for Generalized Anxiety Disorder GAD was established in two 8-week, placebo-controlled, fixed-dose studies 75 to mg per day , one 6-month, placebo-controlled, flexible-dose study 75 to mg per day , and one 6-month, placebo-controlled, fixed-dose study
In moderately depressed outpatients, the initial dose of venlafaxine was 75 mg per day.
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In another study, the data on more than , cases were obtained from the UK general practice research database.
For more information about Effexor XR call or go to www.
Tumors were not increased by venlafaxine treatment in mice or rats.
In rare cases, drug-induced akathisia can occur after use in some people.
Across all clinical studies with Effexor, 1.
Effexor XR is also used to treat:.
Such complications can arise immediately upon delivery.
The neurotransmitters affected are serotonin and norepinephrine.
Not all pack sizes may be marketed.
Increases Compared to Placebo.
Pharmacologic activity at these receptors is hypothesized to be associated with the various anticholinergic, sedative, and cardiovascular effects seen with other psychotropic drugs.
Healthcare professionals are advised to prescribe Effexor and Effexor XR in the smallest quantity of capsules consistent with good patient management to reduce the risk of overdose.
Venlafaxine is not recommended in patients hypersensitive to it, nor should it be taken by anyone who is allergic to the inactive ingredients, which include gelatin , cellulose , ethylcellulose, iron oxide , titanium dioxide and hypromellose.
Take the venlafaxine packet, or the leaflet inside it, plus any remaining medicine with you.
Sustained blood pressure elevation can lead to adverse outcomes.
It is also sometimes used to treat anxiety and panic attacks.
Venlafaxine is one of a group of antidepressants called serotonin and noradrenaline reuptake inhibitors, or SNRIs.
For people with a history of seizures: Venlafaxine raises your risk of seizures.
In the clinical studies establishing efficacy, upward titration was permitted at intervals of 2 weeks or more.
Coadministration of Effexor XR and weight loss agents is not recommended.
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Venlafaxine extended release is chemically the same as normal venlafaxine.
This can lead to death.
You can report any suspected side effect to the UK safety scheme.
Control pre-existing hypertension before initiating treatment with Effexor XR.
Venlafaxine side effects in more detail.
Availability Prescription only.
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Patients should be made aware of the potential risk of serotonin syndrome.
Venlafaxine indirectly affects opioid receptors as well as the alpha2-adrenergic receptor, and was shown to increase pain threshold in mice.
People with a history of increased eye pressure or glaucoma should have their eye pressure checked regularly while taking venlafaxine.
See also: Effexor side effects in more detail.
Venlafaxine has not been properly tested with recreational drugs.
A study conducted in Finland followed more than 15, patients for 3.
Advise patients that they should have regular monitoring of blood pressure when taking Effexor XR [see Warnings and Precautions 5.
Breastfeeding will also benefit both you and your baby.
This is to help prevent any extra side effects you might get as a reaction to coming off the medicine.
Tell your healthcare provider about all the medicines that you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Take Venlafaxine tablets at approximately the same time each day, in the morning and in the evening, with food.
Check with your doctor before starting to take venlafaxine if you: have had an allergic reaction to venlafaxine or any other medicines in the past have a heart problem - as venlafaxine can speed up or change your heartbeat are trying to become pregnant, are already pregnant or you are breastfeeding have an eye problem called glaucoma because venlafaxine can increase the pressure in your eye have epilepsy or are having electroconvulsive treatment - venlafaxine may increase your risk of having a seizure If you have diabetes , venlafaxine can make it more difficult to keep your blood sugar stable.
If you have a seizure, stop taking venlafaxine and call your doctor right away.
It can be potentially dangerous to take venlafaxine with:.
These are not all the possible side effects of Effexor XR.
Patients should be advised of the following issues and should be asked to alert their prescriber if these occur while taking Effexor XR.
Cannabis can also make drowsiness worse with venlafaxine, especially in people who have just started taking it.
SNRIs work by increasing the levels of substances called serotonin and norepinephrine in your brain.
Venlafaxine may interact with other medications.
The need for continuing medication in patients with PD who improve with Effexor XR treatment should be periodically reassessed.
If you take Effexor XR , you should not take any other medicines that contain venlafaxine including: venlafaxine HCl.
The pooled analyses of placebo-controlled studies in children and adolescents with MDD, Obsessive Compulsive Disorder OCD , or other psychiatric disorders included a total of 24 short-term studies of 9 antidepressant drugs in over 4, patients.
Venlafaxine can be taken by adults for depression, anxiety and panic attacks.
Your dosage, drug form, and how often you take the drug will depend on:.
Talk to you doctor before using this drug if breastfeeding.
Your doctor may start you on a low dosage and monitor you closely if they increase your dosage.
These side effects happen in more than 1 in people.
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Depressed patients who are currently being treated at a therapeutic dose with Effexor immediate release may be switched to Effexor XR at the nearest equivalent dose mg per day , e.
In clinical studies with Effexor XR, tapering was achieved by reducing the daily dose by 75 mg at one-week intervals.
Some medicines and venlafaxine can interfere with each other and increase the chances of you having side effects.
While venlafaxine has not been systematically studied in clinical studies for its potential for abuse, there was no indication of drug-seeking behavior in the clinical studies.
You should use Venlafaxine only after discussing the potential benefits and the potential risks to your unborn child with your doctor.
If you forget to take Venlafaxine Tablets If you miss a dose, take it as soon as you remember.
Suicide is a known risk of depression and certain other psychiatric disorders, and these disorders themselves are the strongest predictors of suicide.
One patient who ingested 2.
In placebo-controlled premarketing studies, there were increases in mean blood pressure see Table
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Talk to your doctor about other drug options that may work for you.
Use caution in treating patients with pre-existing hypertension or cardiovascular or cerebrovascular conditions that might be compromised by increases in blood pressure.
When used with venlafaxine, these drugs can cause dangerous effects in your body.
Reporting of side effects If you get any side effects, talk to your doctor or pharmacist.
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure:.
Reported clinical findings have included respiratory distress, cyanosis, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hypertonia, hyperreflexia, tremor, jitteriness, irritability, and constant crying.
If your doctor has prescribed Venlafaxine for a patient under 18 and you want to discuss this, please go back to your doctor.
Get emergency medical help if you have signs of an allergic reaction to Effexor: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
While these events are generally self-limiting, there have been reports of serious discontinuation symptoms.
Patients receiving continued Effexor XR treatment experienced statistically significantly lower relapse rates over the subsequent 26 weeks compared with those receiving placebo study 4.
Read the Medication Guide that comes with Effexor XR before you start taking it and each time you get a refill.
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Venlafaxine was originally marketed as Effexor in most of the world; generic venlafaxine has been available since around and extended release venlaxafine has been available since around
Effexor XR treatment for up to 8 weeks and up to 6 months in premarketing placebo-controlled GAD trials was associated with mean final on-therapy increases in serum cholesterol concentration of approximately 1.
You may see an improvement in your symptoms after a week although it usually takes between 4 and 6 weeks before you feel the full benefits.
Effexor XR and other antidepressant medicines may cause serious side effects, including:.
Similar improvement was observed in both groups.
Efficacy was established in four week and one week, placebo-controlled trials.
Contents of the pack and other information 1.
Venlafaxine may increase suicidal thoughts or actions in some children and young adults.
These effects can increase the pressure in your eyes.
If needed, your doctor may increase the dose gradually up to a maximum of mg daily.
If you have problems with your liver or kidneys your doctor might prescribe a lower dose.
No reports involved the administration of methylene blue by other routes such as oral tablets or local tissue injection or at lower doses.
Ask your doctor before taking a nonsteroidal anti-inflammatory drug NSAID for pain, arthritis, fever, or swelling.
Tell your doctor right away if you become pregnant while taking Effexor.
These risk differences drug-placebo difference in the number of cases of suicidality per 1, patients treated are provided in Table 1.
It is important to continue taking venlafaxine to keep you well.
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
There may be new information.
You may need to decide whether to stop breastfeeding or stop taking this medication.
For children: This drug should not be used in people younger than 18 years of age.
There were suicides in the adult studies, but the number was not sufficient to reach any conclusion about drug effect on suicide.
The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
Also you must wait at least one week after you stop taking Venlafaxine tablets before you can take an MAOI.
Treating depression properly is important to help you get better.
Amiodarone Amphetamines e.
The cause of these deaths is not known.
However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects.
The use of Effexor XR within 14 days of discontinuing treatment with an MAOI intended to treat psychiatric disorders is also contraindicated [see Dosage and Administration 2.
Figure 3: Pharmacokinetics of venlafaxine and its metabolite O-desmethylvenlafaxine ODV in special populations.
A black box warning alerts doctors and patients about drug effects that may be dangerous.
Call your healthcare provider right away if you have any of the following symptoms, or call if an emergency.
In primate drug discrimination studies, venlafaxine showed no significant stimulant or depressant abuse liability.
You will usually take
SSRIs and SNRIs, including Effexor XR, may increase the risk of bleeding events, ranging from ecchymoses, hematomas, epistaxis, petechiae, and gastrointestinal hemorrhage to life-threatening hemorrhage.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.
The higher risk and increased severity of discontinuation syndrome symptoms relative to other antidepressants may be related to the short half-life of venlafaxine and its active metabolite.
Symptoms of an overdose of this drug can include:.
Call your doctor right away if you have serious side effects.
Call your doctor for medical advice about side effects.
Effexor XR should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The concomitant use of Effexor XR with tryptophan supplements is not recommended [see Dosage and Administration 2.
These are warning signs of a serious allergic reaction.
Should the decision be made to treat a pediatric patient with Effexor XR, regular monitoring of weight and height is recommended during treatment, particularly if treatment is to be continued long-term [see Warnings and Precautions 5.
Some doctors may prescribe venlafaxine off label for the treatment of diabetic neuropathy in a similar manner to duloxetine and migraine prophylaxis in some people, however, venlafaxine can exacerbate or cause migraines.
The effect of venlafaxine on the QT interval was evaluated in a randomized, double-blind, placebo- and positive-controlled three-period crossover thorough QT study in 54 healthy adult subjects.
Serotonin syndrome symptoms may include mental status changes e.
Venlafaxine , sold under the brand name Effexor among others, is an antidepressant medication of the serotonin-norepinephrine reuptake inhibitor SNRI class.
In addition, at least 7 days should be allowed after stopping Effexor XR before starting an MAOI intended to treat psychiatric disorders [see Contraindications 4.
Signs and symptoms of NMS may include a combination of fever, fast heart beat, sweating, severe muscle stiffness, confusion, increased muscle enzymes determined by a blood test.
Patients not responding to the initial 75 mg per day dose may benefit from dose increases to a maximum of mg per day.
However, you may have a relapse of depression if you stop taking your antidepressant.
Venlafaxine is usually categorized as a serotonin-norepinephrine reuptake inhibitor SNRI , but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor SNDRI.
Studies have shown that the extended release formula has a lower incidence of nausea as a side effect, resulting in better compliance.
No suicides occurred in any of the pediatric studies.
Having more serotonin and norepinephrine in your brain can improve your symptoms of depression and anxiety.
The usual starting dose of venlafaxine is 75mg a day.
Talk to your doctor if they last longer than a week or are severe.
Headaches should usually go away after the first week of taking venlafaxine.
Capsules contain venlafaxine hydrochloride equivalent to
Not every pharmacy stocks this drug.
This is due to lack of specificity of the screening tests.
Consequently, the precautions for adults apply to pediatric patients [see Warnings and Precautions 5.
A comparative meta-analysis of 21 major antidepressants found that venlafaxine, agomelatine , amitriptyline , escitalopram , mirtazapine , paroxetine , and vortioxetine were more effective than other antidepressants although the quality of many comparisons was assessed as low or very low.
Venlafaxine may cause serious lung problems in a newborn if the mother takes the medicine late in pregnancy during the third trimester.
It may also affect your ability to make decisions, think clearly, or react quickly.
At baseline, patients prescribed venlafaxine had a greater number of risk factors for suicide such as prior suicide attempts than patients treated with other anti-depressants.
Examination of subsets of the population studied did not reveal any differential responsiveness on the basis of gender.
Talk with your healthcare provider if there is something you do not understand or want to learn more about.
Therefore, you should take special care with your dental hygiene.
Generic drugs usually cost less than brand-name drugs.
Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies.
Signs of Depression.
Pre-existing glaucoma is almost always open-angle glaucoma because angle closure glaucoma, when diagnosed, can be treated definitively with iridectomy.
You may need to read it again.
Tell your doctor immediately, or go to the casualty department at your nearest hospital if you think serotonin syndrome is happening to you.
Venlafaxine is a substrate of P-glycoprotein P-gp , which pumps it out of the brain.
Venlafaxine and ODV have been reported to be excreted in human milk.
Your doctor will need to check your progress at regular visits while you are using venlafaxine.
See also: Venlafaxine dosage information in more detail.
Food and Drug Administration for all antidepressants.
Administration of Effexor XR mg once daily generally resulted in lower C max and later T max values than for Effexor immediate release administered twice daily Table
Advise patients to notify their physician if they develop allergic phenomena such as rash, hives, swelling, or difficulty breathing.
How do I come off venlafaxine?
Dosage adjustment based on the age or gender of a patient is generally not necessary [see Dosage and Administration 2.
Some may be better suited for you than others.
Venlafaxine Tablets 75 mg and
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This drug should only be used if the potential benefit justifies the potential risk to the fetus.
If you remember just a few hours before your next scheduled dose, take only one dose.
See also: Venlafaxine drug interactions in more detail.
You may find it helpful to tell a relative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet.
The primary route of excretion of venlafaxine and its metabolites is via the kidneys.
People with severe liver disease or cirrhosis may need an even lower dosage.
People who are on dialysis should take half of the typical dosage.
In these two studies, Effexor XR was statistically significantly more effective than placebo for each fixed dose on all three endpoints, but a dose-response relationship was not clearly established.
Effexor XR may be associated with these serious side effects :.
People stopping venlafaxine commonly experience discontinuation symptoms such as dysphoria , headaches , nausea , irritability , emotional lability , sensation of electric shocks, and sleep disturbance.
A few people may get sexual side effects, such as problems getting an erection or a lower sex drive.
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The following symptoms, anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia psychomotor restlessness , hypomania, and mania, have been reported in adult and pediatric patients being treated with antidepressants for MDD, as well as for other indications, both psychiatric and nonpsychiatric.
Venlafaxine drug interactions in more detail.
During marketing of Effexor XR, other SNRIs, and SSRIs, there have been spontaneous reports of adverse events occurring upon discontinuation of these drugs, particularly when abrupt, including the following: dysphoric mood, irritability, agitation, dizziness, sensory disturbances e.
If your symptoms are severe, call or go to the nearest emergency room.
The extended release controlled release version distributes the release of the drug into the gastrointestinal tract over a longer period than normal venlafaxine.
Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Discontinuation symptoms have been systematically evaluated in patients taking venlafaxine, including prospective analyses of clinical studies in GAD and retrospective surveys of studies in MDD and SAD.
The pupillary dilation that occurs following use of many antidepressant drugs including Effexor XR may trigger an angle closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy.
Give a list of all your medicines to any healthcare provider who treats you.
The complete text of the Medication Guide is reprinted at the end of this document.
An analysis of clinical trials by the FDA statisticians showed the incidence of suicidal behaviour among the adults on venlafaxine to be not significantly different from fluoxetine or placebo.
Your doctor will need to check your progress at regular visits while you are using Effexor.
For more information, ask your healthcare provider or pharmacist.
If acceptable alternatives to linezolid or intravenous methylene blue are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patient, Effexor XR should be stopped promptly, and linezolid or intravenous methylene blue can be administered.
Serious side effects and their symptoms can include the following:.
These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older [see Warnings and Precautions 5.
Non- clinical studies have demonstrated that venlafaxine and its active metabolite, ODV, are potent and selective inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake.
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The pooled analyses of placebo-controlled studies in adults with MDD or other psychiatric disorders included a total of short-term studies median duration of 2 months of 11 antidepressant drugs in over 77, patients.
They may want to review your treatment.
Talk to your doctor if you think you might take any while taking venlafaxine.
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Give the medicine at least 6 weeks to work.
Venlafaxine may impair your thinking or reactions.
Symptoms may include:.
This may be the result of a blood disorder which leads to an increased risk of infection.
How to take Venlafaxine Tablets Always take this medicine exactly as your doctor has told you.
The risk of using venlafaxine in combination with other CNS-active drugs has not been systematically evaluated.
There is no specific antidote for venlafaxine, and management is generally supportive, providing treatment for the immediate symptoms.
Drug release is controlled by diffusion through the coating membrane on the spheroids and is not pH-dependent.
Skin and appendages — Urticaria, pruritus, rash, alopecia.
If it is not treated, your condition may not go away and may become more serious and more difficult to treat.
The possibility of these adverse events should be considered in venlafaxine-treated patients who present with progressive dyspnea, cough or chest discomfort.
According to the FDA analysis of clinical trials  venlafaxine caused a statistically significant 5-fold increase in suicidal ideation and behaviour in persons younger than
In both studies, Effexor XR demonstrated superiority over placebo on the primary efficacy measure defined as change from baseline in the HAM-D total score to the endpoint visit, Effexor XR also demonstrated superiority over placebo on the key secondary efficacy endpoint, the Clinical Global Impressions CGI Severity of Illness scale.
Therapy with Effexor XR can be resumed 24 hours after the last dose of linezolid or intravenous methylene blue [see Warnings and Precautions 5.
Eur equivalent to Venlafaxine
It might be best to stop drinking alcohol during the first few days of treatment until you see how this medicine affects you.
Dose increases should be in increments of up to 75 mg per day, as needed, and should be made at intervals of not less than 7 days.
It is not known whether or not the dose of Effexor XR needed for maintenance treatment is identical to the dose needed to achieve an initial response.
Special senses — Angle-closure glaucoma [see Warnings and Precautions 5.
Additionally, in high doses it weakly inhibits the reuptake of dopamine ,  with recent evidence showing that the norepinephrine transporter also transports some dopamine as well, since dopamine is inactivated by norepinephrine reuptake in the frontal cortex.
Some of the common side effects of venlafaxine will gradually improve as your body gets used to it.
Effexor XR is not indicated for weight loss alone or in combination with other products.
Do not stop using venlafaxine without first talking to your doctor.
In most cases, no signs or symptoms were associated with overdose.
After adjusting for known risk factors, venlafaxine was associated with an increased risk of suicide relative to fluoxetine and dothiepin that was not statistically significant.
Interstitial lung disease and eosinophilic pneumonia associated with venlafaxine therapy have been rarely reported.